This article discusses the struggles of women in Santander against social, economic and political inequity, and the impacts of climate change. Three cases from this northwest Colombian region are examined. The first is a group of countrywomen in the Andean region impacted by desertification and drought. Their action plan is an integrated approach that includes gender relations and environmental conservation facets. These women often stay on the land they have no legal authority over, enduring water shortages, performing domestic duties, and leading social change campaigns while the men leave in search of work. The second case involves two groups of fisherwomen of the River Magdalena who are displaced by armed conflict and climate crisis. Their priorities are food sovereignty, and the role of women in social transformation seeking to resolve rural environmental problems. These women have been affected by extreme climatic shifts resulting in droughts and floods. They are striving to protect their wetlands, and resisting the impacts of extensive farming, mining and petroleum exploitation, and palm oil plantations. The third case addresses displaced women, vulnerable women and social networks facing climate crisis due to flooding in the Bucaramanga metropolitan area. They have launched initiatives to promote sovereign food production and strengthening self-esteem.